Rutgers University researchers have uncovered a protein from gut parasitic worms that accelerates wound healing in mice. This protein, when applied to skin wounds, not only quickens healing but also enhances skin regeneration and reduces scarring. Groundbreaking Wound Healing Research Scientists at ...
Stories by Rockefeller University Press
Researchers have uncovered a new mechanism by which Huntington’s disease causes neuronal death. They found that toxic protein aggregates from a mutated huntingtin protein can damage the nuclear envelope, leading to DNA damage and gene misregulation in neurons. This breakthrough could link similar me...
Researchers at the Weizmann Institute of Science in Israel have identified a yeast that could be used to prevent invasive candidiasis, a major cause of death in hospitalized and immunocompromised patients. The study, recently published in the Journal of Experimental Medicine (JEM), shows that the no...
Boosting neuron production in Alzheimer’s mice restores memory, indicating that enhancing neurogenesis may offer a new treatment approach for Alzheimer’s disease. Scientists have discovered that increasing the production of new neurons in mice with Alzheimer’s disease (AD) rescues the an...
Stanford cancer team uses the custom molecule sBCMA-Fc V3 to inhibit the development of diffuse large B cell lymphoma and multiple myeloma in mice. Researchers at Stanford University have created “decoy receptor” molecules that prevent the development of diffuse large B cell lymphoma (DL...
A drug named C26 activates NR2F1 protein, forcing cancer cells into dormancy and preventing metastasis in mice. A new therapeutic approach prevents the growth of metastatic tumors in mice by forcing cancer cells into a dormant state in which they are unable to proliferate. The study, published in th...
Cancer Drug Shows Promise in Treating Infants With Incurable Disease That Causes Tissue Overgrowth
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Alpelisib has shown promise in treating young infants with PROS, a group of disorders caused by PIK3CA mutations, by significantly improving severe symptoms without adverse effects. PIK3CA-related overgrowth spectrum (PROS) is a group of rare, incurable disorders caused by mutations in the PIK3...
Yale Researchers Develop RNA-Based Therapy That Can Protect From Range of COVID-19 Variants
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Yale researchers found that SLR14, an RNA molecule, stimulates antiviral defenses and protects mice against various COVID-19 variants, offering a potential low-cost treatment option. Researchers at Yale School of Medicine have discovered that an RNA molecule that stimulates the body’s early antivira...
Researchers discovered that poisonous frogs and birds likely rely on “toxin sponge” proteins, rather than resistant sodium channels, to avoid self-intoxication from batrachotoxin.  A team of researchers from the University of California, San Francisco (UCSF), Stanford University, and the Califo...
TDP-43 is essential for cholesterol production and uptake in myelin-forming brain cells. Loss of this protein disrupts myelin maintenance, linking cholesterol metabolism defects to ALS and FTD. Restoring cholesterol may offer a new treatment avenue. Researchers in Singapore have discovered that brai...
New Drug That Could Prevent Alzheimer’s Disease Found Safe and Effective in Animals
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A Safe, Plaque-Reducing Alzheimer’s Drug May Be Ready for Human Trials Researchers at the University of California San Diego School of Medicine and Massachusetts General Hospital have identified a new drug that could prevent Alzheimer’s disease by modulating, rather than inhibiting, a key enzy...
Activating the STING pathway and engineering IL-17A-producing CAR T cells greatly improved breast cancer treatment in mice, offering hope for effective solid tumor therapies. Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of geneti...